Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) (p87); Papain-like protease nsp3 (PL-PRO) (EC 3.2.2.-) (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (p195); Non-structural protein 4 (nsp4) (Peptide HD2) (p41); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (p33); Non-structural protein 6 (nsp6) (p34); Non-structural protein 7 (nsp7) (p9); Non-structural protein 8 (nsp8) (p24); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9) (p10); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p16); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p68); Proofreading exoribonuclease (ExoN) (EC 2.1.1.-) (EC 3.1.13.-) (Guanine-N7 methyltransferase) (Non-structural protein 14) (nsp14) (p58); Uridylate-specific endoribonuclease (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15) (p39); 2'-O-methyl transferase (EC 2.1.1.57) (Non-structural protein 16) (nsp16) (p35)]